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Latest News/Research

Micro-dosing concept. Psilocybin mushrooms isolated on ivory background. Psychedelic trip, magic mushroom. Alternative medicine.
Research Summary

Is psilocybin an effective antidepressant and what is its mechanism of action?

Psilocybin, the active compound in "magic mushrooms," has shown promise as an effective antidepressant in clinical trials, particularly for individuals with treatment-resistant depression and major depressive disorder. Its mechanism of action is thought to involve a combination of serotonin receptor activation, neural plasticity, altered brain network connectivity, and psychological factors. However, further research is needed to optimize dosing, treatment duration, and therapeutic settings, as well as to fully understand its long-term safety and efficacy.
by The ShrumLane Team August 19, 2022
Dry Psilocybe Cubensis mushrooms in a glass jar on a wooden board surrounded by indoor plants. Life style microdosing concept.
Research Summary

How Important Is a Guide Who Has Taken Psilocybin in Psilocybin-Assisted Therapy for Depression?

This study investigated the impact of a guide's personal experience with psilocybin on the therapeutic outcomes of psilocybin-assisted therapy for depression. The results revealed no significant difference in the reduction of depressive symptoms between patients guided by therapists with or without personal psilocybin experience, suggesting that a guide's personal experience may not be a crucial factor in determining the success of this therapy. However, the authors acknowledge several limitations, including a small sample size and not examining other factors such as empathy or rapport between the guide and the patient.
by The ShrumLane Team March 24, 2022
Microdosing concept. Dry psilocybin mushrooms on black background. Natural organic supplement. Medical usage. Psychedelic magic trip.
Research Summary

How Important Is a Guide Who Has Taken Psilocybin in Psilocybin-Assisted Therapy for Depression?

This study investigated the impact of a guide's personal experience with psilocybin on the therapeutic outcomes of psilocybin-assisted therapy for depression. The results revealed no significant difference in the reduction of depressive symptoms between patients guided by therapists with or without personal psilocybin experience, suggesting that a guide's personal experience may not be a crucial factor in determining the success of this therapy. However, the authors acknowledge several limitations, including a small sample size and not examining other factors such as empathy or rapport between the guide and the patient.
by The ShrumLane Team March 24, 2022
Dry Psilocybe Cubensis mushrooms on a wooden board surrounded by indoor plants. Life style microdosing concept.
Research Summary

The Use of Psilocybin in the Treatment of Psychiatric Disorders with Attention to Relative Safety Profile: A Systematic Review

This systematic review examines the therapeutic potential and safety profile of psilocybin, a naturally occurring psychoactive compound, in treating psychiatric disorders such as treatment-resistant depression, anxiety disorders, obsessive-compulsive disorder, substance use disorders, and post-traumatic stress disorder. The findings suggest that psilocybin demonstrates promising efficacy, particularly for treatment-resistant depression, anxiety disorders, and obsessive-compulsive disorder, with a favorable safety profile compared to conventional treatments. However, further research is needed to establish long-term effects, optimal treatment parameters, and to address limitations in the current literature, such as small sample sizes and lack of control groups.
by The ShrumLane Team March 1, 2022
12-month follow-up 1 5-HT2A receptor 2 abstinence rates 1 acute effects 1 addiction 3 addiction treatment 1 advanced cancer 1 adverse effects/events/reactions 3 alcohol consumption 1 Alcohol Use Disorder (AUD) 4 alternative medications 1 alternative treatment 1 antidepressants 3 anxiety 18 athletes 1 attitudes 1 attitudes towards death 1 ayahuasca 1 bad trips 1 bipolar disorder 1 body dysmorphic disorder (BDD) 1 body mass index (BMI) 1 brain network connectivity 1 breakthrough therapy 4 cancer patients 4 clinical applications 1 clinical environment 1 clinical trial 2 clinical trials 4 clinically meaningful response 1 cluster headache 1 co-occurring disorders 1 cognitive functioning 1 cognitive-behavioral therapy (CBT) 3 commodification 1 connectedness 1 controlled trial 1 courses 1 decriminalization 1 default mode network 1 dependence 1 depression 17 depression severity 1 depressive symptoms 0 DMT 1 double-blind 5 efficacy 4 emotional challenges 1 emotional eating 1 emotional release 1 emotional well-being 1 empathy 2 end-of-life care 1 ethical implications 1 existential distress 2 food addiction 1 functioning 1 guide 2 guided trip 1 hallucinogen persisting perception disorder (HPPD) 1 hallucinogenic mushrooms 1 Hamilton Depression Rating Scale 2 harm potential 1 harm reduction 1 headache frequency 1 headache intensity 1 healing process 1 heavy drinking days 1 history 1 implementing insights 1 improved mood 1 indigenous cultures 1 individual differences 1 individual factors 1 interconnectedness 1 international survey 0 introspection 1 Jamaica 1 lasting antidepressant effect 1 legal barriers 1 legal hurdles 1 legalization 1 life-threatening cancer 1 limitations 3 long COVID 1 long-term effects 1 low-dose pulse regimen 1 LSD 3 magic mushrooms 7 mainstream healthcare 1 major depression 1 major depression disorder 1 major depressive disorder (MDD) 7 manic episodes 0 manic symptoms 1 MDMA 3 meaning response 1 mechanism of action 1 mental health 10 mental health treatment 2 meta-analysis 3 microdosing 2 Moms on Mushrooms 1 Montgomery-Asberg Depression Rating Scale (MADRS) 2 mood regulation 0 mycotherapy 1 Netherlands 1 neurobiological mechanisms 0 neuroplasticity 6 nonrandomized controlled trial 1 novel treatment 1 obesity 1 obsessive-compulsive disorder (OCD) 2 online community 1 openness 1 paranoia 1 participant experiences 1 performance enhancement 1 personal experience 2 personal growth 2 pharmacotherapy 2 physical pain 1 physiological responses 1 pilot study 1 placebo-controlled 4 post-traumatic stress disorder (PTSD) 7 potential risks 1 psilocybin 25 Psilocybin therapy 2 psilocybin truffle retreat 1 psilocybin-assisted psychotherapy 1 psilocybin-assisted therapy 16 psychedelic integration 1 psychedelic research 1 psychedelic-assisted therapy 3 psychedelics 6 psychiatric disorders 1 psychiatric illness 1 psycho-social-spiritual well-being 2 psychological distress 1 psychological flexibility 1 psychological growth 1 psychological responses 1 psychotherapists 1 psychotherapy 6 qualitative analysis 2 quality of life 7 randomized 1 randomized controlled trial 8 rapport 2 regulatory barriers/challenges 2 relationships 1 remission 1 research 2 research implications 1 resilience 1 resistance 1 retreat setting 1 risks 5 safety 8 scalable model 1 scientific research 1 self-awareness 1 self-reflection 1 self-report 0 serotonergic system 2 serotonin 2A receptors 1 serotonin agonist 1 set and setting 1 severe depression 1 side effects 3 single-dose 1 social challenges 1 spiritual experiences 3 spiritual well-being 2 standardized treatment protocols 1 stress 1 stress-induced weight gain 1 structured support 1 substance 1 substance use disorders 2 suicidality 1 survey 1 symptom reduction 1 systematic review 1 thematic analysis 1 therapeutic outcomes 2 therapeutic potential/benefits 7 therapeutic relationship 2 therapeutic settings/environment 2 toxicity 1 training 1 transformative experiences 2 treatment 1 treatment efficacy 3 treatment option 1 treatment-resistant depression 4 vulnerable populations 1 web-based questionnaire 0 wellness 1 Yale-Brown Obsessive Compulsive Scale 1
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